Who We Are
SteroTherapeutics is pursuing novel drug therapies for orphan diseases, or diseases that are often life-threatening, and which affect fewer than 200,000 people in the United States. Our mission is to develop treatments that also have the potential to treat more common, large-market diseases.
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We have established partnerships with some of the world’s leading academic research institutions and organizations.
ST-002
Cushing's Syndrome
Our lead program, ST-002 targets Cushing's syndrome. Cushing’s is caused by elevated levels of cortisol, which can manifest in obesity, diabetes, hypertension, cardiovascular disease, and immune dysfunction. Cushing's, an orphan disease, is poorly served by currently available therapies with limited efficacy and deleterious side effects. SteroTherapeutics entered into a Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health (NIH) to develop a novel treatment for Cushing’s syndrome patients. ST-002 may also have the potential to treat non alcoholic steatohepatitis, or NASH, an advanced form of non-alcoholic fatty liver disease that impacts up to 6% of the world’s population, or nearly 500 million people.
ST-003
Primary Sclerosing Cholingitis
The second program, ST-003, is targeting the treatment of Primary Sclerosing Cholingitis (PSC). PSC is a rare, heterogeneous, immune inflammatory disorder of the bile ducts resulting in cholestasis due to strictures of the intrahepatic and and extrahepatic bile ducts. Although the great majority of PSC patients have inflammatory bowel disease (IBD), only ~ 5% of IBD patients will develop PSC and the underlying causes of the association remains poorly understood. However, ST-003 may have the potential to treat
the PSC comorbid IBD, as well as IBD itself, which affects an estimated 3.1 million adults in the US alone, or 1.3% of the US adult population.