Differentiated Anti-Glucocorticoid Effect
Excess Glucocorticoid exposure produces numerous deleterious physiologic and metabolic effects. It includes weight gain, hyperglycemia, immune suppression, bone loss, and muscle loss.
Currently used drugs to treat excess Glucocorticoid exposure are unselective in their action and suppress the anti-inflammatory action of Glucocorticoids. This anti-inflammatory action of Glucocorticoid is beneficial when an individual experiences an infection or trauma. Suppression of this anti-inflammatory action can lead to the symptom of adrenal insufficiency which in the case of sepsis can be life-threatening.
ST-002 is a selective Anti-glucocorticoid which suppresses many of its deleterious effects but does not antagonize its anti-inflammatory action.